A Comparison of Dobutamine, Norepinephrine, Vasopressin, and Hetastarch for the Treatment of Isoflurane-Induced Hypotension in Healthy, Normovolemic Dogs

Isoflurane is a commonly used inhalation anesthetic in species undergoing veterinary care that induces hypotension, impacting organ perfusion, making it imperative to minimize its occurrence or identify effective strategies for treating it. This study evaluated and compared the hemodynamic effects of DOB, NEP, VAS, HES twelve isoflurane-anesthetized Beagle dogs. The order first three treatments was randomized. administered last. Data were collected before (baseline) after 10 min sustained MAP <45 mmHg induced by high end-tidal isoflurane concentration (T0). Once treatment initiated target achieved (65 80 mmHg) maximum dose reached, data 15 stabilization (T1) (T2). A washout period with ≥65 allowed between treatments. intravenous dosage regimens started increased 50% every five minutes until reached. dosages as follows: 5–15 μg/kg/min; 0.1–2 0.5–5 mU/kg/min; HET, 6% 1–20 mL/kg/min. DOB improved CO, DO2, VO2, but reduced SVR. VAS elevated SVR, decreased VO2. minimally changed BP mildly augmented These failed reach MAP. NEP arterial BP, MPAP, PAWP, HR. Norepinephrine infusion at 0.44 ± 0.19 μg/kg/min most efficient therapy correcting isoflurane-induced hypotension.